True about Apoptosis all EXCEPT –
**Core Concept**
Apoptosis is a form of programmed cell death, a vital process that eliminates damaged or unwanted cells from the body. It involves a series of cellular changes, including DNA fragmentation, chromatin condensation, and membrane blebbing.
**Why the Correct Answer is Right**
Apoptosis is a tightly regulated process that involves the activation of caspases, a family of cysteine proteases. The execution of apoptosis is often initiated by the activation of pro-apoptotic proteins, such as BAX and BAK, which form pores in the mitochondrial outer membrane, releasing cytochrome c and activating the caspase cascade. This process is crucial for maintaining tissue homeostasis and preventing the development of cancer.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because apoptosis is indeed characterized by DNA fragmentation, which occurs in the presence of endonucleases that cleave the DNA into smaller fragments.
**Option B:** This option is incorrect because apoptosis involves the activation of caspases, which are responsible for the proteolytic cleavage of various cellular substrates, leading to the characteristic morphological changes of apoptosis.
**Option C:** This option is incorrect because apoptosis is a distinct process from necrosis, which is a form of cell death that occurs due to acute cellular injury or infection.
**Clinical Pearl / High-Yield Fact**
A key feature of apoptosis is the absence of inflammation, as the dying cells are quickly phagocytosed by macrophages, preventing the release of pro-inflammatory mediators.
**Correct Answer: Not Given. Please provide the other options.**