INH and pyridoxine are given together in antituberculous chemotherapy :
**Core Concept**
The use of isoniazid (INH) in antituberculous chemotherapy can lead to **pyridoxine deficiency**, as INH interferes with the metabolism of **pyridoxine (Vitamin B6)**. This can result in neurological side effects.
**Why the Correct Answer is Right**
INH and pyridoxine are given together to prevent **peripheral neuropathy**, a common side effect of INH due to its interference with pyridoxine metabolism. Pyridoxine supplementation helps mitigate this risk by ensuring adequate levels of **pyridoxal phosphate**, the active form of Vitamin B6.
**Why Each Wrong Option is Incorrect**
**Option A:** Not relevant to the context of INH and pyridoxine supplementation.
**Option B:** Incorrect, as INH does not typically require supplementation with other vitamins in this context.
**Option C:** Not applicable, as the question is about the combination of INH and pyridoxine.
**Option D:** Incorrect, as this option does not address the specific reason for pyridoxine supplementation with INH.
**Clinical Pearl / High-Yield Fact**
Remember, **pyridoxine supplementation** is crucial when using INH to prevent **peripheral neuropathy**, a significant side effect of INH therapy.
**Correct Answer:** D. to prevent peripheral neuropathy