Antitubercular drug causing gout is:-
**Core Concept**
The question tests knowledge of **antitubercular drugs** and their side effects, specifically the one that can cause **gout**. This is related to the **pharmacology** of these drugs and their potential to affect **purine metabolism**.
**Why the Correct Answer is Right**
Pyrazinamide is known to cause **hyperuricemia** by inhibiting the renal excretion of **uric acid**, leading to an increased risk of **gout**. This is a well-documented side effect of pyrazinamide, making it a critical consideration in the management of **tuberculosis**.
**Why Each Wrong Option is Incorrect**
**Option A:** Not specified, but typically other antitubercular drugs like isoniazid or rifampicin do not have a significant association with gout.
**Option B:** Not specified, but ethambutol is more commonly associated with **optic neuritis**.
**Option D:** Not specified, but other drugs are less likely to cause gout compared to pyrazinamide.
**Clinical Pearl / High-Yield Fact**
It's essential to monitor **uric acid levels** in patients taking pyrazinamide and consider **prophylactic measures** to prevent gout, such as **allopurinol** or **febuxostat**.
**Correct Answer:** D. Pyrazinamide.