**Core Concept**
The question requires knowledge of the pharmacological properties of antipsychotic medications, specifically their effects on blood pressure. Antipsychotics can cause hypotension due to their blockade of alpha-1 adrenergic receptors, which are involved in vasoconstriction and blood pressure regulation.
**Why the Correct Answer is Right**
Risperidone is a second-generation antipsychotic that has a high affinity for alpha-1 adrenergic receptors. By blocking these receptors, risperidone can cause vasodilation and a subsequent decrease in blood pressure, leading to hypotension. This effect is more pronounced in risperidone compared to other antipsychotics due to its pharmacological profile.
**Why Each Wrong Option is Incorrect**
**Option A:** Haloperidol is a first-generation antipsychotic that is more likely to cause hyperprolactinemia and extrapyramidal side effects rather than hypotension.
**Option B:** Olanzapine is a second-generation antipsychotic that is more likely to cause weight gain and metabolic side effects rather than hypotension.
**Option C:** Quetiapine is a second-generation antipsychotic that is more likely to cause sedation and weight gain rather than hypotension.
**Clinical Pearl / High-Yield Fact**
When initiating antipsychotic therapy, it is essential to monitor blood pressure regularly, especially in patients with a history of cardiovascular disease or those taking other medications that can cause hypotension.
**Correct Answer:** C. Risperidone.
Free Medical MCQs Β· NEET PG Β· USMLE Β· AIIMS
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