**Core Concept**
Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by the presence of antiphospholipid antibodies, which increase the risk of thrombosis and pregnancy complications such as recurrent miscarriages. The management of APS in pregnancy involves anticoagulation therapy to prevent thrombotic events and improve pregnancy outcomes.
**Why the Correct Answer is Right**
Low-dose aspirin is recommended in women with antiphospholipid antibodies and a history of prior abortions or stillbirth to reduce the risk of thrombotic events and improve pregnancy outcomes. Aspirin acts by inhibiting platelet aggregation and reducing the production of thromboxane A2, a potent vasoconstrictor. This mechanism helps to prevent thrombus formation and improve blood flow to the placenta, thereby reducing the risk of pregnancy complications.
**Why Each Wrong Option is Incorrect**
**Option A:** Heparin is often used in conjunction with low-dose aspirin in women with APS to provide additional anticoagulation. However, it is not the primary recommendation for this patient population.
**Option B:** Warfarin is contraindicated in pregnancy due to its teratogenic effects and inability to cross the placenta, making it an inappropriate choice for this patient.
**Option C:** Corticosteroids are not a primary treatment for APS and may actually increase the risk of thrombosis.
**Clinical Pearl / High-Yield Fact**
Low-dose aspirin is a critical component of antiphospholipid syndrome management in pregnancy, and its use should be initiated early in pregnancy to maximize benefits.
**Correct Answer:** C. Low-dose aspirin
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