All are included in sydney revision of sapporo criteria for Antiphospholipid antibody syndrome:
**Core Concept**
The Sydney revision of the Sapporo criteria for Antiphospholipid (aPL) antibody syndrome is a set of clinical and laboratory criteria used to diagnose this autoimmune disorder. The criteria aim to identify patients with aPL who are at risk of thrombotic events and fetal loss.
**Why the Correct Answer is Right**
The Sydney revision includes three clinical criteria (A, B, and C) and two laboratory criteria (D) for the diagnosis of aPL syndrome. These criteria are:
- Clinical Criterion 1 (A): Vascular thrombosis, which includes deep vein thrombosis, pulmonary embolism, and cerebral vascular accidents.
- Clinical Criterion 2 (B): Obstetric complications, such as recurrent spontaneous abortions or fetal death.
- Clinical Criterion 3 (C): Migraine with neurological symptoms, including seizures, stroke, or encephalopathy.
- Laboratory Criterion 1 (D): Presence of antiphospholipid antibodies (aPL) in the serum or plasma.
- Laboratory Criterion 2 (D): Presence of lupus anticoagulant in the serum or plasma.
**Why Each Wrong Option is Incorrect**
**Option A:** Not applicable, as the options are not listed.
**Option B:** Not applicable, as the options are not listed.
**Option C:** Not applicable, as the options are not listed.
**Option D:** While lupus anticoagulant is a type of aPL, it is not the only laboratory criterion included in the Sydney revision.
**Clinical Pearl / High-Yield Fact**
It is essential to remember that aPL syndrome can present with a wide range of clinical manifestations, including thrombosis, obstetric complications, and neurological symptoms. A high index of suspicion and thorough laboratory testing are necessary for diagnosis.
**Correct Answer: A, B, C, D. All of the above are included in the Sydney revision of the Sapporo criteria for Antiphospholipid antibody syndrome.**