Antiparkinson drug known to cause cardiac valvular fibrosis is ?
Correct Answer: Pergolide & cabergo line
Description: Ans. is 'd' i.e., Pergolide & cabergoline o Ergot-containing dopamine receptor agonists used for Parkinson's disease (pergolide, cabergoline, bromocriptine) cause valvular hea disease that closely resembles that seen in the carcinoid syndrome. o Metabolites of fenfluramine, as well as the dopamine receptor agonists, have high affinity for serotonin receptor subtype 5-HT2B receptors, whose activation is known to cause fibroblast mitogenesis. Serotonin receptor subtypes 5-HTI81 D2A2B normally are expressed in human hea valve intersitial cells. o High levels of HT2B receptors are known to occur in hea valves and occur in cardiac fibroblasts and cardiomyocytes.
Category:
Pharmacology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now