An example of a preventive antioxidant is:
**Core Concept**
Catalase is an enzyme that plays a crucial role in the breakdown of hydrogen peroxide (H2O2), a toxic byproduct of cellular metabolism, into water and oxygen. This process is a prime example of a preventive antioxidant mechanism, where the enzyme neutralizes the oxidizing agent before it can cause damage to cellular components.
**Why the Correct Answer is Right**
Catalase (EC 1.11.1.6) catalyzes the decomposition of hydrogen peroxide into water and oxygen through a two-step reaction: H2O2 β H2O + O2. This enzyme is found in the peroxisomes of cells, where it helps to detoxify H2O2 and prevent oxidative damage to cellular membranes and organelles. By breaking down H2O2, catalase prevents the formation of highly reactive hydroxyl radicals, which can cause cellular damage and contribute to various diseases.
**Why Each Wrong Option is Incorrect**
**Option B:** Tocopherol (vitamin E) is an antioxidant that works by scavenging free radicals, but it does not break down hydrogen peroxide like catalase.
**Option C:** Superoxide dismutase (SOD) is another antioxidant enzyme that dismutates superoxide anions (O2-) into hydrogen peroxide and oxygen, which is then broken down by catalase.
**Option D:** Urate is a byproduct of purine metabolism and has antioxidant properties, but it is not an enzyme that breaks down hydrogen peroxide.
**Clinical Pearl / High-Yield Fact**
Remember that antioxidants like catalase and SOD work in tandem to prevent oxidative damage. While catalase breaks down hydrogen peroxide, SOD dismutates superoxide anions to form hydrogen peroxide, which is then neutralized by catalase.
**Correct Answer:**
β Correct Answer: A. Catalase.