## **Core Concept**
The question tests knowledge of antihypertensive drugs and their side effects, specifically the ability to cause a Systemic Lupus Erythematosus (SLE)-like reaction. This reaction is a well-documented side effect of certain medications, characterized by symptoms similar to those of SLE, an autoimmune disease.

## **Why the Correct Answer is Right**
The correct answer, , is known to cause an SLE-like reaction. This class of drugs, specifically **Hydralazine** (a direct vasodilator used in hypertension treatment), is associated with drug-induced lupus erythematosus (DILE), a condition that mimics SLE but is caused by certain medications. The mechanism involves the formation of autoantibodies, likely due to alterations in the immune response.

## **Why Each Wrong Option is Incorrect**
- **Option A:** is not commonly associated with SLE-like reactions. It is a beta-blocker used primarily in the treatment of hypertension and certain types of angina.
- **Option B:** does not typically cause SLE-like reactions. It is an ACE inhibitor used in the treatment of hypertension and heart failure.
- **Option D:** is not commonly linked with SLE-like reactions. It is a calcium channel blocker used to treat hypertension and angina.

## **Clinical Pearl / High-Yield Fact**
A key point to remember is that **Hydralazine** and **Procainamide** are classic causes of drug-induced lupus erythematosus (DILE), an SLE-like reaction. This association is crucial for medical students and professionals to recognize, as it can guide drug selection and monitoring in patients with hypertension or other conditions.

## **Correct Answer:** . Hydralazine