## Core Concept
The management of hypertension in pregnancy requires careful consideration of both the mother's and the fetus's health. Certain antihypertensive drugs are contraindicated in pregnancy due to their potential to harm the fetus or interfere with pregnancy outcomes.
## Why the Correct Answer is Right
ACE inhibitors (Angiotensin-Converting Enzyme inhibitors) are known to be contraindicated in pregnancy, particularly after the first trimester, due to the risk of fetal harm, including renal damage and oligohydramnios. They can cause a decrease in fetal renal function leading to oligohydramnios, and also affect fetal blood pressure regulation. This makes **ACE inhibitors** a class of drugs that should be avoided in pregnant women.
## Why Each Wrong Option is Incorrect
* **Option A:** Although not specified, some antihypertensives like Methyldopa, Labetalol, and Nifedipine are commonly used in pregnancy-induced hypertension.
* **Option B:** Similarly, without specifics, it's known that certain drugs are used in pregnancy.
* **Option D:** Again, specifics are needed but generally, some antihypertensives are safe or used cautiously in pregnancy.
## Clinical Pearl / High-Yield Fact
A key point to remember is that **ACE inhibitors** and **Angiotensin Receptor Blockers (ARBs)** are contraindicated in pregnancy due to their association with fetal renal damage and other complications. For managing hypertension in pregnancy, Methyldopa is often considered a first-line agent due to its long history of safe use.
## Correct Answer: C. ACE inhibitors.
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