## **Core Concept**
The question tests knowledge of antifungal medications, specifically their routes of administration. Antifungal drugs can be administered through various routes, including oral and intravenous (IV). The question focuses on identifying an antifungal that can be given orally but not intravenously.
## **Why the Correct Answer is Right**
Voriconazole is an antifungal medication that can be administered orally. It is effective against a wide range of fungal infections. However, it is not typically given intravenously due to its formulation and potential for adverse effects when administered through that route.
## **Why Each Wrong Option is Incorrect**
* **Option A:** Fluconazole can be administered both orally and intravenously, making it incorrect for this question.
* **Option B:** Amphotericin B is primarily administered intravenously, although there are other formulations like liposomal Amphotericin B. It can be given intravenously, not orally as a standard practice.
* **Option C:** Itraconazole can be given orally but also has an intravenous formulation, particularly for certain clinical scenarios.
## **Clinical Pearl / High-Yield Fact**
A key point to remember is that while many antifungals have multiple routes of administration, the specific formulation and clinical use can dictate their typical use. For example, voriconazole's oral formulation is commonly used, but its use intravenously is less common due to potential side effects.
## **Correct Answer:** . Voriconazole
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