Antidote of datura poisoning is
**Core Concept**
Datura poisoning is caused by anticholinergic toxicity, which leads to an overactivation of the sympathetic nervous system, resulting in symptoms such as tachycardia, mydriasis, and delirium. The antidote for Datura poisoning should ideally counteract these effects by increasing cholinergic activity.
**Why the Correct Answer is Right**
Physostigmine is a reversible cholinesterase inhibitor that increases the concentration of acetylcholine in the synaptic cleft, thereby counteracting the anticholinergic effects of Datura alkaloids. This action helps to reverse symptoms such as tachycardia, mydriasis, and delirium. Physostigmine also has a narrow therapeutic index and should be used with caution in patients with cardiac conduction abnormalities.
**Why Each Wrong Option is Incorrect**
* **Option A:** Atropine is an anticholinergic agent that would exacerbate the symptoms of Datura poisoning, rather than treating them.
* **Option B:** Activated charcoal may be used as a prophylactic measure to prevent absorption of Datura alkaloids, but it is not an effective antidote.
* **Option C:** Naloxone is an opioid antagonist and has no role in the management of Datura poisoning.
**Clinical Pearl / High-Yield Fact**
Physostigmine is a specific antidote for Datura poisoning, but its use is limited by its narrow therapeutic index and potential for cardiac arrhythmias. It should be used with caution and only in severe cases of anticholinergic toxicity.
**Correct Answer: C. Physostigmine**