**Core Concept**
Atypical depression is a subtype of major depressive disorder characterized by mood reactivity, increased appetite or weight gain, excessive sleep, heavy or leaden feeling in the limbs, and sensitivity to rejection. It requires a specific treatment approach that differs from typical depression.

**Why the Correct Answer is Right**
The correct answer is a medication that targets the increased appetite and excessive sleep seen in atypical depression. Bupropion, a norepinephrine-dopamine reuptake inhibitor (NDRI), is used in the treatment of atypical depression due to its ability to increase the levels of norepinephrine and dopamine in the brain. This leads to a decrease in appetite and sleepiness, making it a suitable choice for patients with atypical depression.

**Why Each Wrong Option is Incorrect**
**Option A:** Selective serotonin reuptake inhibitors (SSRIs) are commonly used in the treatment of depression but are not the first-line treatment for atypical depression. They may even exacerbate the excessive sleep and appetite seen in atypical depression.
**Option B:** Tricyclic antidepressants (TCAs) are effective in treating depression but are not typically used as a first-line treatment for atypical depression due to their side effects and risk of overdose.
**Option C:** Monoamine oxidase inhibitors (MAOIs) are effective in treating depression but are not typically used as a first-line treatment for atypical depression due to dietary restrictions and potential interactions with other medications.

**Clinical Pearl / High-Yield Fact**
Bupropion is unique among antidepressants in its ability to decrease appetite and sleepiness, making it a good choice for patients with atypical depression. However, it can also increase anxiety and seizures as side effects.

**Correct Answer:** B. Bupropion