## Core Concept
Tricyclic antidepressants (TCAs) are a class of medications primarily used to treat depression and certain other conditions like neuropathic pain and migraines. They work by inhibiting the reuptake of serotonin and norepinephrine. However, their use comes with several limitations due to their side effects and pharmacological profile.

## Why the Correct Answer is Right
The correct answer, which is not listed in the query but implied to be one of the options provided (A, B, C, D), needs to be evaluated based on common limitations of TCAs. Typical limitations include anticholinergic side effects (e.g., dry mouth, constipation, urinary retention), cardiac effects (e.g., arrhythmias, QT prolongation), and potential for overdose. Without the specific options provided, a general understanding is that TCAs have various side effects that limit their use.

## Why Each Wrong Option is Incorrect
- **Option A:** If this option describes a well-known side effect or limitation of TCAs (e.g., anticholinergic effects, cardiac toxicity), it would be incorrect because the question asks for an EXCEPT.
- **Option B:** Similarly, if this option outlines another recognized limitation (e.g., weight gain, sexual dysfunction), it would not be the correct answer because it indeed represents a limitation.
- **Option C:** This would also be incorrect if it represents a common issue with TCAs, such as the risk of serotonin syndrome or the need for careful monitoring of plasma levels.
- **Option D:** This option is stated as the correct answer, implying it does NOT represent a typical limitation of TCAs.

## Clinical Pearl / High-Yield Fact
A significant clinical pearl regarding TCAs is that, despite their limitations, they are still effective for treating depression, especially in patients who have not responded to other treatments. However, their use requires careful patient selection and monitoring due to potential side effects.

## Correct Answer Line
Given the structure of the question and standard knowledge about TCAs, without specific details on A, B, C, or D, we proceed based on the instruction: **Correct Answer: D.**