**Core Concept**
The question is testing the knowledge of selecting an antidepressant that is safe for patients with hypotension and cardiac disease. This involves understanding the pharmacological effects of various antidepressants on the cardiovascular system.

**Why the Correct Answer is Right**
The correct answer is **Mirtazapine**, which is a tetracyclic antidepressant that has a favorable profile for patients with hypotension and cardiac disease. Mirtazapine has a neutral or slightly positive effect on blood pressure due to its alpha-2 adrenergic antagonist properties, which counteract the alpha-1 adrenergic receptor-mediated vasoconstriction. Additionally, it does not significantly affect heart rate or cardiac conduction.

**Why Each Wrong Option is Incorrect**
**Option A:** **Selective Serotonin Reuptake Inhibitors (SSRIs)** such as Fluoxetine can cause orthostatic hypotension due to their effect on serotonin levels and blood pressure regulation.
**Option B:** **Tricyclic Antidepressants (TCAs)** like Amitriptyline can exacerbate cardiac disease due to their anticholinergic effects, which can increase heart rate and cardiac workload.
**Option C:** **Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs)** like Venlafaxine can increase blood pressure due to their norepinephrine reuptake inhibition, which can be problematic for patients with cardiac disease.

**Clinical Pearl / High-Yield Fact**
When selecting an antidepressant for patients with cardiac disease, it's essential to consider the medication's effects on cardiovascular parameters, such as blood pressure and heart rate.

**Correct Answer:** C. Mirtazapine.