Sunder, a young male was diagnosed as suffering from acute myeloid leukemia. He was staed on induction chemotherapy with Anticancer drugs. Induction regimen was successful. Two months later, he presents to OPD with swelling of both the feet and breathlessness on climbing the stairs. He also complains the he had to wake up many times because of breathlessness. Which of the following is most likely responsible for this patient’s symptoms?
Sunder, a young male was diagnosed as suffering from acute myeloid leukemia. He was staed on induction chemotherapy with Anticancer drugs. Induction regimen was successful. Two months later, he presents to OPD with swelling of both the feet and breathlessness on climbing the stairs. He also complains the he had to wake up many times because of breathlessness. Which of the following is most likely responsible for this patient’s symptoms?
💡 Explanation
**Core Concept**
The patient's symptoms suggest a condition affecting the heart, likely as a side effect of chemotherapy. **Cardiotoxicity** is a well-known complication of certain anticancer drugs. The symptoms of swelling, breathlessness, and nocturnal dyspnea are indicative of **heart failure**.
**Why the Correct Answer is Right**
Although the correct answer is not provided, a common cause of cardiotoxicity in this context is the use of **anthracyclines**, such as doxorubicin, which are frequently used in the treatment of acute myeloid leukemia. These drugs can cause damage to the **cardiac myocytes**, leading to a decrease in **left ventricular function** and ultimately resulting in heart failure.
**Why Each Wrong Option is Incorrect**
**Option A:** Without the specific answer choices, it's challenging to provide detailed explanations for each incorrect option. However, in general, options that do not relate to cardiotoxicity or heart failure would be incorrect.
**Option B:** Similarly, without the specific text, any option not implicating a direct cardiac side effect of chemotherapy would be wrong.
**Option C:** An option suggesting an unrelated condition, such as an infection or a different type of cancer, would not explain the patient's cardiac symptoms.
**Option D:** Any choice not associated with the cardiac effects of chemotherapy would be incorrect.
**Clinical Pearl / High-Yield Fact**
A key point to remember is that **anthracyclines** can cause **cardiomyopathy**, which may lead to heart failure. Monitoring of cardiac function is crucial in patients receiving these drugs.
**Correct Answer:** Not provided in the query.
✓ Correct Answer: C. Doxorubicin
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