**Core Concept**
Antibody transfer across the placenta is a crucial aspect of fetal immunology, where maternal antibodies protect the fetus from infections. This process is mediated by the presence of specific receptors and transport mechanisms in the placenta.
**Why the Correct Answer is Right**
The transfer of antibodies across the placenta is primarily facilitated by the Fc receptors present on the placental syncytiotrophoblast cells. These receptors bind to the Fc region of IgG antibodies, allowing them to cross the placental barrier. The size of the antibody also plays a crucial role, as IgG antibodies are the only class that can cross the placenta due to their smaller size.
**Why Each Wrong Option is Incorrect**
**Option A:** IgM antibodies are too large to cross the placenta, making them an incorrect choice.
**Option B:** IgA antibodies are primarily found in mucosal secretions and do not cross the placenta.
**Option C:** IgE antibodies are involved in allergic reactions and are not transferred across the placenta.
**Clinical Pearl / High-Yield Fact**
The ability of IgG antibodies to cross the placenta is essential for protecting the fetus from infections, such as rubella and tetanus. This highlights the importance of maintaining adequate maternal IgG levels through vaccination and proper healthcare.
**Correct Answer: D. IgG**
Free Medical MCQs Β· NEET PG Β· USMLE Β· AIIMS
Access thousands of free MCQs, ebooks and daily exams.
By signing in you agree to our Privacy Policy.