Antibody shown to be useful for Crohn’s Disease is:
**Core Concept**
The question is testing the use of biologics in the treatment of Crohn's disease, a type of inflammatory bowel disease (IBD). The correct answer involves an antibody that targets a specific molecule involved in the immune response.
**Why the Correct Answer is Right**
The correct answer is **vedolizumab**, an anti-integrin antibody that targets the Ξ±4Ξ²7 integrin receptor on the surface of T lymphocytes. This receptor plays a crucial role in the homing of T cells to the gut-associated lymphoid tissue (GALT), which is a key site of inflammation in Crohn's disease. By blocking the Ξ±4Ξ²7 integrin, vedolizumab reduces the infiltration of T cells into the gut, thereby decreasing inflammation and improving symptoms.
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is incorrect because the described antibody is not used in the treatment of Crohn's disease. The actual antibody used in Crohn's disease is a different one.
* **Option B:** This option is incorrect because the described antibody is not used in the treatment of Crohn's disease. The actual antibody used in Crohn's disease is a different one.
* **Option C:** This option is incorrect because the described antibody is not used in the treatment of Crohn's disease. The actual antibody used in Crohn's disease is a different one.
**Clinical Pearl / High-Yield Fact**
It's essential to remember that biologics, such as vedolizumab, are a class of medications that target specific molecules involved in the immune response. They are often used to treat autoimmune diseases, including Crohn's disease, and can be effective in reducing inflammation and improving symptoms.
**Correct Answer:** C.