Pathology Antibodies against double stranded DNA and smooth muscle antigens are virtually diagnostic of: A Systemic sclerosis B Systemic Lupus Erythematosus C Sjogren's disease D Wegener's granulomatosis 💡 Explanation Antibodies against double stranded DNA and smooth muscle antigens are virtually diagnostic of: ✓ Correct Answer: B. Systemic Lupus Erythematosus