There is already under-expression of TNF-α in SLE, therefore we cannot use anti-TNF drugs for this condition. It is further strengthened by the fact that anti-TNF alpha drugs like infliximab cause SLE as the adverse effect. Indications for TNF-α inhibitorsRheumatoid arthritis Juvenile arthritis Psoriatic arthritis Psoriasis Ankylosing spondylitis Crohn's disease