It is seen in scleroderma. Limited form of scleroderma known as CREST has anti centromere antibody positive and generalized form has anti topoisomerase positive antibody Anti histone antibodies are positive in drug induced lupus Anti SS-A (RO) antibodies and anti SS-B(LA) antibodies are positive in Sjogren's Syndrome Most specific antibody in SLE is anti nuclear antibody and most specific antibody is anti ds-DNA and Anti smith antibody Presence of anti P antibody is associated with development if psychosis /CNS manifestation in SLE patients Presence of anti RO antibody is associated with development of cutaneous lupus and congenital hea block Presence of b2 glycoprotein is associated with development of Antiphospholipid antibody