**Core Concept**
Anthropozoonosis refers to the transmission of zoonotic diseases from animals to humans, often through direct or indirect contact. This concept is crucial in understanding the epidemiology and control of infectious diseases.

**Why the Correct Answer is Right**
Schistosomiasis is a parasitic disease caused by the Schistosoma species, which is primarily transmitted through contact with contaminated water. Unlike other options, schistosomiasis is typically acquired through human-to-human contact or contaminated water sources, rather than through direct contact with infected animals. This makes it an exception to the definition of anthropozoonosis.

**Why Each Wrong Option is Incorrect**
**Option A:** Rabies is a classic example of an anthropozoonosis, where the virus is transmitted from infected animals (usually bats, dogs, or cats) to humans through bites or scratches.
**Option B:** Plague is another zoonotic disease, caused by Yersinia pestis, which can be transmitted from infected rodents to humans through fleas or direct contact.
**Option C:** Anthrax is a bacterial disease caused by Bacillus anthracis, which can be transmitted from infected animals to humans through contact with contaminated animal products or spores.

**Clinical Pearl / High-Yield Fact**
When considering the transmission of zoonotic diseases, it's essential to remember the " Three Cs" of transmission: contact (direct or indirect), contaminated food or water, and vectors (such as fleas, ticks, or mosquitoes).

**✓ Correct Answer: D. Schistosomiasis**