**Core Concept**
Opioid receptor antagonists, also known as opioid antagonists or opioid receptor blockers, are a class of medications that block the action of opioids at their receptor sites. They are used to reverse opioid overdose, treat opioid addiction, and manage opioid-induced side effects.

**Why the Correct Answer is Right**
The correct answer will be the statement that is not true about opioid receptor antagonists. Opioid receptor antagonists work by binding to opioid receptors in the body and blocking the action of opioids. This can help to reverse the effects of opioid overdose, including respiratory depression and sedation. Naloxone is a commonly used opioid receptor antagonist that is administered in emergency situations to reverse opioid overdose.

**Why Each Wrong Option is Incorrect**
**Option A:** Opioid receptor antagonists can be used to treat opioid addiction. This statement is true, as opioid receptor antagonists can help to reduce cravings and prevent relapse in individuals with opioid use disorder.
**Option B:** Opioid receptor antagonists can cause physical dependence. This statement is false, as opioid receptor antagonists do not cause physical dependence or addiction.
**Option C:** Opioid receptor antagonists can be used to manage opioid-induced constipation. This statement is true, as opioid receptor antagonists can help to reverse opioid-induced constipation.
**Option D:** Opioid receptor antagonists can be used to treat pain. This statement is false, as opioid receptor antagonists are not typically used to treat pain, as they can actually worsen pain in some cases.

**Clinical Pearl / High-Yield Fact**
Opioid receptor antagonists should be used with caution in individuals with a history of substance abuse or addiction, as they can precipitate withdrawal symptoms in individuals who are physically dependent on opioids.

**Correct Answer:** B. Opioid receptor antagonists can cause physical dependence.