## **Core Concept**
The question tests knowledge of the pharmacological properties of certain drugs, specifically their action on serotonin (5HT4) receptors and dopamine (D2) receptors. 5HT4 agonists can enhance gastrointestinal motility and are used in treating conditions like gastroparesis. D2 antagonists have various applications, including antiemetic and antipsychotic effects.
## **Why the Correct Answer is Right**
Metoclopramide is known for its dual action as a 5HT4 receptor agonist and a D2 receptor antagonist. As a 5HT4 agonist, it enhances acetylcholine release in the gastrointestinal tract, thereby increasing gastrointestinal motility. As a D2 antagonist, it blocks dopamine receptors in the chemoreceptor trigger zone of the central nervous system, exerting antiemetic effects and also contributing to its prokinetic effects.
## **Why Each Wrong Option is Incorrect**
- **Option A:** This option is incorrect because while it might represent a drug with some similar properties, its specific actions as a 5HT4 agonist and D2 antagonist are not detailed here, but based on the correct answer, it's clear that metoclopramide fits the description best.
- **Option B:** This option does not match the description provided for metoclopramide.
- **Option D:** This option also does not match the dual action described.
## **Clinical Pearl / High-Yield Fact**
A key clinical pearl is that metoclopramide's use can lead to extrapyramidal side effects (like dystonia) due to its D2 antagonist properties, especially in young adults and children. This is a critical consideration in its prescription.
## **Correct Answer:** C. Metoclopramide
Free Medical MCQs Β· NEET PG Β· USMLE Β· AIIMS
Access thousands of free MCQs, ebooks and daily exams.
By signing in you agree to our Privacy Policy.