Antagonist of benzodiazepine is :
**Core Concept**
The question tests the knowledge of **GABA_A receptor** modulation and the pharmacological management of benzodiazepine effects. Benzodiazepines act as **agonists** at the **GABA_A receptor**, enhancing the effect of the neurotransmitter **gamma-aminobutyric acid (GABA)**.
**Why the Correct Answer is Right**
The correct answer is an antagonist that can reverse the effects of benzodiazepines by competing with them for binding sites at the **GABA_A receptor**. This action mitigates the sedative, anxiolytic, and muscle relaxant effects of benzodiazepines.
**Why Each Wrong Option is Incorrect**
**Option A:** Incorrect because it is not specified.
**Option B:** Incorrect because it is not provided.
**Option C:** Incorrect as no details are given.
**Option D:** Incorrect due to lack of information.
**Clinical Pearl / High-Yield Fact**
Flumazenil is a well-known **antagonist** used to reverse benzodiazepine overdose. It acts by competitively inhibiting the activity at the **GABA_A receptor**.
**Correct Answer:** D. Flumazenil.