Antacid interfere with absorption of all of the following except:
Correct Answer: Azithromycin
Description: Ketoconazole dissolves at low pH: gastric acid is needed for its absorption.Therefore antacid interfere with its absorption.
Tetracyclines have chelating property- form insoluble and unabsorbable complexes with calcium and other metals. Milk, iron preparations, nonsystemic antacids and sucralfate reduce their absorption. Administration of these substances and tetracyclines should be staggered, if they cannot be avoided altogether.
Azithromycin: The improved pharmacokinetic properties are acid-stability, rapid oral absorption (from empty stomach), larger tissue distribution and intracellular penetration.
Reference: Essentials of Medical Pharmacology Eighth Edition KD TRIPATHI page no 21,786,763,804
Category:
Pharmacology
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