### Core Concept
Primary open-angle glaucoma (POAG) is a progressive optic neuropathy characterized by the degeneration of retinal ganglion cells, leading to visual field loss. It is the most common form of glaucoma, accounting for approximately 90% of all glaucoma cases. POAG is often associated with increased intraocular pressure (IOP), but the exact pathophysiology remains multifactorial.

### Why the Correct Answer is Right
POAG is a chronic condition that results from the interplay of various factors, including increased IOP, age-related degeneration of the optic nerve, and genetic predisposition. Key players in the pathogenesis of POAG include the trabecular meshwork, a sponge-like network of tissue that regulates aqueous humor outflow from the eye. The outflow of aqueous humor is critical in maintaining normal IOP levels.

### Why Each Wrong Option is Incorrect
**Option A:** Not applicable, as this option is missing.
**Option B:** Not a correct association, but without the actual option, we cannot determine the incorrect association.
**Option C:** Not a correct association, but without the actual option, we cannot determine the incorrect association.
**Option D:** Not a correct association, but without the actual option, we cannot determine the incorrect association.

### Clinical Pearl / High-Yield Fact
POAG is often asymptomatic in its early stages, making regular eye exams crucial for early detection and treatment. The primary treatment strategy for POAG involves reducing IOP through medications, laser therapy, or surgery to prevent further optic nerve damage.

### Correct Answer Line
Correct Answer: D.