**Core Concept**
Primary Angle Closure glaucoma is a medical emergency characterized by a sudden increase in intraocular pressure (IOP) due to the iris occluding the trabecular meshwork. The primary goal of treatment is to rapidly reduce IOP and prevent further damage to the optic nerve.

**Why the Correct Answer is Right**
The drug of choice for the treatment of an acute attack of primary Angle Closure glaucoma is a carbonic anhydrase inhibitor, such as acetazolamide. Acetazolamide works by inhibiting the enzyme carbonic anhydrase in the ciliary body, which reduces aqueous humor production and subsequently lowers IOP. This rapid reduction in IOP is essential in preventing further damage to the optic nerve and preserving vision.

**Why Each Wrong Option is Incorrect**
**Option A:** Beta blockers, such as timolol, are used to reduce IOP in glaucoma patients by decreasing aqueous humor production, but they are not the drug of choice for an acute attack of primary Angle Closure glaucoma due to their slower onset of action.
**Option B:** Alpha agonists, such as brimonidine, are used to reduce IOP in glaucoma patients by decreasing aqueous humor production and increasing uveoscleral outflow, but they are not the drug of choice for an acute attack of primary Angle Closure glaucoma due to their slower onset of action.
**Option C:** Prostaglandin analogs, such as latanoprost, are used to reduce IOP in glaucoma patients by increasing uveoscleral outflow, but they are not the drug of choice for an acute attack of primary Angle Closure glaucoma due to their slower onset of action.

**Clinical Pearl / High-Yield Fact**
In addition to acetazolamide, other treatments for acute Angle Closure glaucoma include hyperosmotic agents (such as mannitol) and topical beta agonists (such as epinephrine). It's essential to remember that the treatment of choice will depend on the severity of the attack and the patient's underlying medical conditions.

**Correct Answer: C. Acetazolamide.**