Angiotensin conveing enzyme inhibitors when used for a long time in patients with hypeension, cause:
Correct Answer: Reduction in glomerular filtration fraction
Description: Unlike the direct-acting smooth muscle vasodilators or adrenergic inhibitors, ACE inhibitors dilate the efferent as well as the afferent glomerular aerioles and thereby reduce glomerular hydrostatic pressure and renal filtration fraction, even though renal blood flow and glomerular filtration rate are preserved. Ref: KD Tripathi 8th ed.
Category:
Pharmacology
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