Not true about angioneurotic edema ?
**Core Concept**
Angioneurotic edema is a severe, life-threatening allergic reaction characterized by the rapid swelling of the skin and mucous membranes. It can be caused by various factors, including medication, insect stings, and food allergies.
**Why the Correct Answer is Right**
Angioneurotic edema typically presents with non-pitting edema, which means that the swelling does not leave an indentation when pressed. This is in contrast to pitting edema, which is often associated with conditions such as heart failure or liver disease. The correct answer, **Option A**, is incorrect because angioneurotic edema is characterized by non-pitting edema, not pitting edema. The swelling of the face, lips, and mucous membranes in angioneurotic edema is often non-pitting and can be extremely severe.
**Why Each Wrong Option is Incorrect**
**Option B:** C1 Esterase inhibitor deficiency is indeed a cause of angioneurotic edema, specifically Hereditary Angioedema (HAE). This condition is characterized by recurrent episodes of severe angioedema, often without urticaria.
**Option C:** Extreme temperature exposure is not a known provoker of angioneurotic edema. While temperature extremes can trigger other allergic reactions, such as urticaria or heat rash, they are not typically associated with angioneurotic edema.
**Option D:** ACE inhibitors are indeed known to cause angioneurotic edema as a rare but serious side effect. This is thought to occur due to the inhibition of angiotensin-converting enzyme (ACE), which also breaks down bradykinin, a peptide involved in the pathogenesis of angioedema.
**Clinical Pearl / High-Yield Fact**
One key point to remember is that angioneurotic edema can be triggered by a variety of factors, including medication, and can be a medical emergency requiring prompt treatment. Patients with a history of angioedema should be counseled on the risks of certain medications, such as ACE inhibitors.
**β Correct Answer: A. Pitting edema of face, lips and mucous membrane**