**Core Concept:** Angioid streaks are linear depigmentation of the choroid, a characteristic feature of certain inherited connective tissue disorders, most commonly in association with systemic lupus erythematosus (SLE), and less commonly in association with Down syndrome, rheumatoid arthritis, and other connective tissue disorders. These streaks are due to the destruction of the Bruch's membrane and choriocapillaris, leading to reduced vascularization of the underlying choroid.

**Why the Correct Answer is Right:** Angioid streaks appear in the context of certain inherited connective tissue disorders. In this case, the correct answer is related to the underlying pathophysiology of the condition. The streaks result from the destruction of the Bruch's membrane and choriocapillaris, which leads to reduced vascularization of the choroid, causing the characteristic depigmentation.

**Why Each Wrong Option is Incorrect:**

A. This option is incorrect because angioid streaks are not directly associated with systemic lupus erythematosus (SLE). While SLE can lead to angioid streaks, the correct answer focuses on the underlying cause in the context of connective tissue disorders.

B. This answer is incorrect because angioid streaks are not associated with rheumatoid arthritis as their primary cause. Although rheumatoid arthritis can be present concurrently with angioid streaks, the correct answer emphasizes the cause in the context of connective tissue disorders.

C. This answer is incorrect as angioid streaks are not directly associated with Down syndrome. While Down syndrome may lead to angioid streaks, the correct answer highlights the cause in the context of connective tissue disorders.

D. This answer is incorrect because angioid streaks are not directly linked to other connective tissue disorders. While other connective tissue disorders can cause angioid streaks, the correct answer focuses on the primary cause in the context of connective tissue disorders.

**Clinical Pearl:** While studying for these types of questions, it is essential to remember the different associations between various connective tissue disorders and angioid streaks. However, the correct answer highlights the cause in the context of these disorders, emphasizing the destruction of Bruch's membrane and choriocapillaris as the primary cause of angioid streaks. Remembering these associations can help differentiate between the correct answer and the incorrect options, which focus on the concurrent conditions rather than the primary cause.