Angiographically,the typical “beaded” or “pile of plates”appearance involving the internal carotid acry is seen In –
Correct Answer: Fibromuscular dysplasia
Description: Fibromuscular dysplasia is a hyperplastic disorder that affects medium-size and small aeries. It occurs predominantly in females and usually involves the renal and carotid aeries but can affect extremity vessels such as the iliac and subclan aeries. The histologic classification includes intimal fibroplasia, medial dysplasia, and adventitial hyperplasia. Medial dysplasia is subdivided into medial fibroplasia, perimedial fibroplasia, and medial hyperplasia.fibroplasia is the most common type and is characterized by alternating areas of thinned media and fibromuscular ridges. The internal elastic lamina usually is preserved. The iliac aeries are the limb aeries most likely to be affected by fibromuscular dysplasia.It is identified angiographically by a "STRING OF BEADS" appearance caused by thickened fibromuscular ridges contiguous with thin, less-involved poions of the aerial wall. When limb vessels are involved, clinical manifestations are similar to those for atherosclerosis, including claudication and rest pain. PTA and surgical reconstruction have been beneficial in patients with debilitating symptoms or threatened limbs. ref:Harrison&;s principles of internal medicine,ed 18,pg no 2069
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