**Core Concept**
Angiogenesis is the process of new blood vessel formation from pre-existing vessels, a crucial aspect of wound healing, tumor growth, and embryonic development. Fibroblast Growth Factors (FGFs) are a family of proteins that regulate various cellular processes, including angiogenesis.

**Why the Correct Answer is Right**
FGF-2, also known as Basic Fibroblast Growth Factor (bFGF), is a potent angiogenic factor that promotes the proliferation, migration, and differentiation of endothelial cells. It stimulates the expression of vascular endothelial growth factor (VEGF) and other angiogenic factors, leading to the formation of new blood vessels. FGF-2 acts by binding to its high-affinity receptor, FGFR1, which triggers a signaling cascade that ultimately leads to the activation of endothelial cells.

**Why Each Wrong Option is Incorrect**
**Option A:** FGF-1 (Acidic Fibroblast Growth Factor, aFGF) is also involved in angiogenesis, but it is less potent than FGF-2. It does not have the same high-affinity receptor as FGF-2 and requires co-receptors for binding.
**Option B:** FGF-4 (Kaposi's sarcoma-associated fibroblast growth factor) is primarily involved in embryonic development and tumor growth, but it is not a primary angiogenic factor like FGF-2.
**Option C:** FGF-8 (Hedgehog-interactive fibroblast growth factor) is involved in embryonic development and tissue patterning, but it does not play a significant role in angiogenesis.

**Clinical Pearl / High-Yield Fact**
FGF-2 is often used in clinical settings to promote wound healing and angiogenesis, particularly in the treatment of diabetic foot ulcers and other chronic wounds.

**Correct Answer:** C.