Ans. is 'b' i.e., Halothane * Among given options halothane is the best answer as other agents are relatively safe in hepatic dysfunction. But it should be kept in mind that pre-existing liver disease and jaundice is not a contraindication to halothane. Unexplained liver dysfunction and jaundice to previous exposure of Halothane is a contraindication. Though not a contraindication, Halothane should be avoided in liver disease, if possible.Important facts hapatotoxicty of anesthetics* All inhalational agent cause mild hapatotoxicty by decreasing hepatic blood flow. Direct hapatotoxicty (Hepatitis, Hepatic necrosis) is caused by Halothane, Trichloroethylene, Chloroform, Carbon tetrachloride and methoxyflurane.* Isoflurane is the agent of choice in liver disease as it has least effect on Hepatic blood flow.* If the patient of halothane hepatitis has to undergo surgery, then the inhalational agent of choice is sevoflurane.