Androgenic activity of the 19 noestosterone nucleus is decreased by ?
Correct Answer: Removal of methyl group at C 19
Description: Ans. is 'b' i.e., Removal of methyl group at C 19Substitution of a 7a-methyl group in 17b-hydroxyestr-4-en-3-one (19-noestosterone) or its 17a-methyl derivative enhanced the androgenic activities of the parent compounds as well as their ability to bind to b protein and to prostate cell nuclei. Thus, 7a, 17a-dimethyl-19-noestosterone had an apparent affinity for bprotein several times higher than that of 5a-dihydrotestosterone.
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Gynaecology & Obstetrics
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