In Testicular Feminisation Syndrome (Androgen Insensitivity Syndrome) Gonadectomy is indicated –
**Core Concept**
Testicular Feminization Syndrome, also known as Androgen Insensitivity Syndrome (AIS), is a genetic disorder affecting male development due to mutations in the androgen receptor gene. This results in the inability of the body to respond to androgens, such as testosterone, leading to a female phenotype despite the presence of testes.
**Why the Correct Answer is Right**
In AIS, the testes produce androgens, but the body is unable to utilize them due to the non-functional androgen receptor. This leads to a high risk of testicular cancer, particularly germ cell tumors. Gonadectomy, or removal of the testes, is therefore indicated to reduce this risk and prevent malignant transformation. The testes also produce estrogen, leading to feminization of the external genitalia, and removal can help alleviate potential complications related to estrogen production.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because testicular feminization syndrome is not an indication for gonadectomy due to lack of androgen insensitivity.
**Option B:** This option is incorrect because AIS is not typically associated with an increased risk of ovarian cancer.
**Option C:** This option is incorrect because the primary indication for gonadectomy in AIS is the risk of testicular cancer, not feminization of the external genitalia.
**Clinical Pearl / High-Yield Fact**
A key aspect of managing patients with AIS is understanding the importance of gonadectomy in reducing the risk of testicular cancer, which can occur in up to 20% of affected individuals.
**Correct Answer: C.** Gonadectomy is indicated in Testicular Feminisation Syndrome (Androgen Insensitivity Syndrome) to reduce the risk of testicular cancer.