A 32 year old male is a known hypeensive and is being planned for cholecystectomy. Which of the following anaesthetic agents is contraindicated in this person?
**Core Concept**
The question is testing the knowledge of contraindications of various anaesthetic agents in patients with hypertension. **Hypertension** is a significant cardiovascular risk factor, and certain anaesthetic agents can exacerbate this condition.
**Why the Correct Answer is Right**
The correct answer is **C. Succinylcholine**. Succinylcholine is a depolarizing muscle relaxant that can cause a significant increase in intracellular sodium levels, leading to a transient but marked increase in intracellular calcium levels. This can cause a hyperkalemic response, which can be particularly problematic in patients with hypertension, as it can lead to cardiac arrhythmias and myocardial infarction.
**Why Each Wrong Option is Incorrect**
**Option A:** Halothane is a volatile anaesthetic agent that can cause hepatotoxicity, but it is not contraindicated in patients with hypertension.
**Option B:** Fentanyl is an opioid anaesthetic agent that can cause hypotension, but it is not contraindicated in patients with hypertension.
**Option D:** Propofol is a short-acting anaesthetic agent that can cause hypotension, but it is not contraindicated in patients with hypertension.
**Clinical Pearl / High-Yield Fact**
It is essential to note that succinylcholine can cause a significant increase in intracellular calcium levels, leading to cardiac arrhythmias and myocardial infarction in patients with hypertension. This is particularly relevant in patients with pre-existing cardiovascular disease.
**Correct Answer: C. Succinylcholine**