Physiology An increase in which of the following parameters will shift the O2 dissociation curve to the left: A Temperature B Paial pressure of CO2 C 2,3 DPG concentration D Oxygen affinity of hemoglobin 💡 Explanation An increase in which of the following parameters will shift the O2 dissociation curve to the left: ✓ Correct Answer: D. Oxygen affinity of hemoglobin