Physiology An increase in which of the following parameters will shift the O2 dissociation curve to the left – A Increased temperature B Increased partial pressure of CO2 C Increased 2, 3 DPG concentration D Increased oxygen affinity of hemoglobin 💡 Explanation An increase in which of the following parameters will shift the O2 dissociation curve to the left - ✓ Correct Answer: D. Increased oxygen affinity of hemoglobin