Among the currently popular antihypeensive agents, angiotensin-conveing enzyme (ACE) inhibitors, such as captopril and enalapril, have been blamed, albeit rarely, for hepatotoxicity (primarily cholestasis and cholestatic hepatitis, but also hepatocellular injury) .Malignant hypeension (whenIV therapy is indicated) - Labetalol, nicardipine, nitroprusside,enalaprilat are preferred.in case of elderly patients with hypeension,diabetes as well as proteinuria without renal failure,enalapril can be used. ref:Harrison&;s principles of internal medicine,ed 18,pg no 628