Microbiology An autoclave sterilizes dental instruments by causing which of the following? A Coagulation and Denaturation of proteins. B Oxidative damage. C Precipitation of nucleic acids. D Disruption of cell membranes. 💡 Explanation An autoclave sterilizes dental instruments by causing which of the following? ✓ Correct Answer: A. Coagulation and Denaturation of proteins.