Anatomy An antidepressant drug which is known to have both high sedative and anticholinergic activity is: A Phenelzine B Amitriptyline C Fluoxetine D Trazodone 💡 Explanation An antidepressant drug which is known to have both high sedative and anticholinergic activity is: ✓ Correct Answer: B. Amitriptyline