An 8-year-old boy presented with altered sensorium, nausea, vomiting, severe headache and right sided weakness. There was no history of trauma. On fuher examination, it was observed that the joints of the child were tender and stiff. Mother gave history of easy bruising along with frequent episodes of epistaxis and hematemesis. Lab findings revealed normal hematocrit with normal platelet count and PT and abnormally prolonged aPTT. Which of the following drugs is approved in the mild and moderate variants of the above disease: –