An 8-year-old boy is evaluated for fatigue. Auscultation reveals a holosystolic murmur best heard at the lower sternal border. Echocardiography reveals apical displacement of the tricuspid valve leaflets, decreased right ventricular volume and atrialisation of the right ventricle. Moderate to severe TR is present. This patient’s condition is believed to be a teratogenic effect of a drug taken during pregnancy. Which one of the following could not have been the side effect of that drug on biological mother of this patient: –