Amyloidosis of kidney may be seen in the following except –
**Core Concept**
Amyloidosis of the kidney is a condition characterized by the deposition of amyloid fibrils in the glomeruli and renal interstitium, leading to renal dysfunction and failure. This condition can be primary (AL amyloidosis) or secondary to chronic inflammatory diseases, infections, or other chronic conditions.
**Why the Correct Answer is Right**
Amyloidosis of the kidney is commonly seen in conditions such as multiple myeloma (AL amyloidosis), chronic inflammatory diseases like rheumatoid arthritis, and chronic infections like tuberculosis. The amyloid fibrils are composed of various proteins, including immunoglobulin light chains, serum amyloid A protein, and transthyretin. The deposition of these fibrils disrupts the normal glomerular filtration barrier, leading to proteinuria, hematuria, and progressive renal failure.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is a common cause of amyloidosis of the kidney and is therefore incorrect.
**Option B:** This option is also a known cause of secondary amyloidosis of the kidney and is incorrect.
**Option C:** This option is not typically associated with amyloidosis of the kidney and is therefore correct.
**Clinical Pearl / High-Yield Fact**
Amyloidosis of the kidney can be diagnosed using renal biopsy, which shows characteristic amyloid deposits under electron microscopy. The biopsy also helps to identify the underlying cause of amyloidosis.
**Correct Answer: C.**