Amyloid depostion and raised serum calcitonin levels are seen in which thyroid tumor?
Correct Answer: Medullary carcinoma
Description: Acellular amyloid deposits derived from calcitonin polypeptides are present in stroma in many cases of medullary thyroid carcinoma. Calcitonin is readily demonstrable within cytoplasm of tumor cells & stromal amyloid by immunohistochemical methods. In addition to circulating calcitonin, secretion of carcinoembryonic antigen by neoplastic cells is useful biomarker, especially for presurgical assessment of tumor load & in calcitonin-negative tumors.
Category:
Pathology
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