Amphotericin B acts on:-
Correct Answer: Cell membrane
Description: Various drugs used in fungal infections with their mechanism of action are: Class of drugs Drugs bf action Polyenes * Amphotericin-B * Nystatin Bind to ergosterol and create pores in cell membrane. 5-flucytosine(5-FC) DNA polymerase inhibitor Azoles * Ketoconazole * Fluconazole * Itraconazole * Clotrimazole * Voriconazole Inhibits the enzyme lanosterol-14-a-demethylase resulting in reduced ergosterol synthesis. Allylamines * Terbinafine * Butenafine * Naftifine Inhibits squalene epoxidase-pores in cell membrane and accumulation of squalene(major factor) Griseofulvin Microtubule inhibition Echinocandins * Caspofungin Inhibit 1,3 beta glucan synthase enzyme resulting in inhibition of cell wall synthesis
Category:
Pharmacology
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