Pharmacology Among the Drugs used in over active bladder, which of the folloeing has minimum CNS Penetration: A Trospium. B Tolterodine. C Solefenacin. D Oxybutynin. 💡 Explanation Among the Drugs used in over active bladder, which of the folloeing has minimum CNS Penetration: ✓ Correct Answer: A. Trospium.