Ammonia causes depletion of which of the following in TCA cycle?
Correct Answer: Alpha-Keto glutarate
Description: In Hyperammonemia (i.e. excess amino groups in cells), a large amount of alpha keto glutarate (intermediate of TCA) combine with an excess of ammonia in cells to form glutamate which fuher give rise to glutamine by taking up more ammonia (see fig). This leads to depletion of alpha-KG. As alpha-KG is an intermediate of TCA cycle, so TCA cycle stops and the brain is affected as brain is highly dependent on this aerobic pathway for energy. So in case of hyper ammonia alpha-ketoglutarate & glutamate will decrease and glutamine will increase.
Category:
Biochemistry
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