**Core Concept**
Aminophylline is a bronchodilator medication used in the management of asthma and chronic obstructive pulmonary disease (COPD). The loading dose of aminophylline is critical for rapid achievement of therapeutic plasma concentrations, which is essential in acute asthma exacerbations.

**Why the Correct Answer is Right**
The loading dose of aminophylline is typically calculated based on the patient's weight and the desired plasma concentration. The recommended loading dose is approximately 5-7 mg/kg, administered intravenously over 20-30 minutes. This allows for rapid achievement of the desired plasma concentration, which is essential in acute asthma exacerbations. The therapeutic plasma concentration of aminophylline is generally considered to be between 8-20 μg/mL.

**Why Each Wrong Option is Incorrect**
* **Option A:** This option is incorrect because it does not provide a specific dose or dosing regimen for aminophylline.
* **Option B:** This option is incorrect because it does not take into account the patient's weight or the desired plasma concentration.
* **Option C:** This option is incorrect because it does not provide a clear dosing regimen or guidance on how to calculate the loading dose.

**Clinical Pearl / High-Yield Fact**
When administering aminophylline, it is essential to monitor the patient's cardiac rhythm and electrocardiogram (ECG) due to the risk of cardiac arrhythmias. The therapeutic plasma concentration of aminophylline should be maintained between 8-20 μg/mL to avoid toxicity.

**Correct Answer: D. 5-7 mg/kg**